As we all know that the circadian clock is one of million boon that the
god give us.
So if there is a disruption in this clock is that will affect our bodies
function? And can causes cancer?
Cell cycle, dividing and dead of cell is closely associated with
circadian clock. So, any disrupt in the circadian rhythm will be linked to
The cell cycle have four phases: G1,S,G2 and then mitosis.
During G1, the tumor suppressor
Rb inhibits transcription factor E2F. Phosphorylation of Rb by cyclin-bound
cyclin dependent kinases (CDK) in late G1 induces dissociation of Rb and
permits E2F-mediated transcription of S-phase-promoting genes.
The G2/M checkpoint prevents cells containing
damaged DNA from entering mitosis (M). Activated CDK1 (cdc2) bound to cyclin B
promotes entry into M-phase.
mutation in these phases will inactivate the tumor suppressor which mean that
will be a cancer.
According to a study
Clock, Cell Division, and Cancer: From Molecules to Organism)
that published in the PubMed it
said: that the disruption in the circadian clock have a deep influence in the
cell division and cancer develop. Also, in bidirectional way which mean that
the malignancies can cause disruption in the circadian clock!
There was a significant link between random circadian clock and
tumorigenesis in many reports.
Early studies in 1960s was shown that the animals who have restricted
their pineal gland or exposed to continue light have increased formation of
However, in humans the epidemiological studies present that working at
night is one of reasons that you can have a cancer resulting that you disrupt
your circadian cycle. Moreover, the study not only present that it also says
its may enhances the progression of exciting tumor!
An experiment was done on mice shows that the time that expose to the UV
light radiation have been linked to skin cancer.